Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | FABP6 | P51161 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23835776 | 0.85 | KDM4E (0.39) | PIK3CAMTORPNPKDM5APARP1 | |
| SCHEMBL25808876 | 0.85 | PKMYT1 (0.41) | PKMYT1PIK3CAMTORPNPKDM5A | |
| SCHEMBL24112448 | 0.84 | NUDT1 (0.40) | PNPCDK5CDK5R1PKN1PKN2 | |
| SCHEMBL24112332 | 0.75 | PKN1 (0.61) | PKN1PKN2PARP1 | |
| SCHEMBL2541920 | 0.72 | CBFB (0.49) | PNPCDK5CDK5R1FABP6MMP12 | |
| SCHEMBL6314907 | 0.71 | PARP1 (0.36) | PNPCDK5CDK5R1FABP6MMP12 | |
| SCHEMBL13544693 | 0.70 | PARP1 (0.44) | PNPCDK5CDK5R1PARP1 | |
| SCHEMBL1203243 | 0.70 | ALDH1A1 (0.39) | PNPPARP1 | |
| SCHEMBL24029084 | 0.70 | PRKCZ (0.42) | PKMYT1PNPKDM5AMMP12PARP1 | |
| SCHEMBL24450350 | 0.70 | PRKCZ (0.42) | PNPKDM5AMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |