Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25783698 | 0.86 | POLB (0.44) | POLBMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL4178450 | 0.85 | CA12 (0.47) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL23835716 | 0.85 | ALDH1A1 (0.45) | POLBMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL20267365 | 0.82 | ALDH1A1 (0.50) | POLBMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL409948 | 0.80 | MEN1 (0.50) | POLBMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL10244858 | 0.79 | KMT2A (0.52) | MEN1KMT2AALDH1A1L3MBTL1LMNA | |
| SCHEMBL536199 | 0.78 | MEN1 (0.46) | POLBMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL24112443 | 0.76 | TDP1 (0.65) | MEN1KMT2AALDH1A1TDP1L3MBTL1 | |
| SCHEMBL18785879 | 0.76 | GPR27 (0.41) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6116171 | 0.76 | GPR119 (0.44) | MEN1KMT2AALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |