Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409948 | 0.94 | MEN1 (0.50) | MEN1KMT2AMAP2K1L3MBTL1ALDH1A1 | |
| SCHEMBL30200709 | 0.83 | GRM5 (0.46) | MEN1KMT2ATRPA1MAP2K1ALDH1A1 | |
| SCHEMBL283358 | 0.83 | GRM5 (0.46) | MEN1KMT2ATRPA1MAP2K1ALDH1A1 | |
| SCHEMBL15190392 | 0.82 | GRM5 (0.44) | KMT2ATRPA1MAP2K1ALDH1A1CYP11B1 | |
| SCHEMBL2773595 | 0.82 | SMN1; SMN2 (0.41) | MEN1KMT2ATRPA1MAP2K1L3MBTL1 | |
| SCHEMBL11520744 | 0.80 | CA12 (0.46) | MAP2K1ALDH1A1CYP11B1CYP11B2MAPT | |
| SCHEMBL646582 | 0.80 | KMT2A (0.49) | MEN1KMT2ATRPA1MAP2K1L3MBTL1 | |
| SCHEMBL392298 | 0.80 | FLT1 (0.51) | MEN1KMT2AALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL24112451 | 0.78 | POLB (0.45) | MEN1KMT2AMAP2K1L3MBTL1ALDH1A1 | |
| SCHEMBL289565 | 0.78 | LRRK2 (0.45) | ALDH1A1CYP11B1CYP11B2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414342-A1 | OXADIAZOLE DERIVATIVES | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112461-A1 | OXADIAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2010-10-07 | — | — | WO | disclosed |