Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 4/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6336102 | 0.98 | SMPD3 (0.47) | SMPD3PDE10APRKDCCDK1CDK2 | |
| SCHEMBL113232 | 0.90 | SMPD3 (0.55) | SMPD3PDE10ACDK1CDK2PTPN11 | |
| SCHEMBL2413653 | 0.86 | SMPD3 (0.47) | SMPD3PDE10APRKDCCDK1CDK2 | |
| SCHEMBL2068649 | 0.84 | SMPD3 (0.46) | SMPD3PDE10APRKDCCDK1CDK2 | |
| SCHEMBL2069373 | 0.84 | SMPD3 (0.46) | SMPD3PDE10APRKDCCDK1CDK2 | |
| SCHEMBL2069375 | 0.84 | SMPD3 (0.46) | SMPD3PDE10APRKDCCDK1CDK2 | |
| SCHEMBL2415129 | 0.82 | HRH4 (0.53) | PDE10APTPN11MAP4K4 | |
| SCHEMBL2410696 | 0.82 | SMPD3 (0.50) | SMPD3PDE10ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL2412342 | 0.81 | SMPD3 (0.43) | SMPD3PDE10APRKDCCDK1CDK2 | |
| SCHEMBL2411465 | 0.81 | PRKAB2 (0.48) | SMPD3PDE10APRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1312606-B1 | 2,5-diaminopyridine oxidation bases and their use for dyeing of keratin fibres | OREAL (FR) | 2011-09-21 | — | — | EP | claimed |
| CN-1250192-C | 2,5-diaminopyridine oxidation color display alkali for dyeing keratin fibre | OREAL (FR) | 2006-04-12 | — | — | CN | claimed |
| US-6837908-B2 | 2,5-diaminopyridine oxidation bases for the dyeing of keratin fibres | L'OREAL S.A. (FR) | 2005-01-04 | — | — | US | claimed |
| US-20030163876-A1 | Novel 2,5-diaminopyridine oxidation bases for the dyeing of keratin fibres | L'OREAL S.A. (FR) | 2003-09-04 | — | — | US | claimed |
| CN-1425365-A | 2,5-diaminopyridine oxidation color display alkali for dyeing keratin fibre | OREAL (FR) | 2003-06-25 | — | — | CN | claimed |
| EP-1312606-A1 | 2,5-diaminopyridine oxidation bases and their use for dyeing of keratin fibres | L'OREAL (FR) | 2003-05-21 | — | — | EP | claimed |
| EP-1312606-B1 | 2,5-diaminopyridine oxidation bases and their use for dyeing of keratin fibres | OREAL (FR) | 2011-09-21 | — | — | EP | disclosed |
| EP-1312606-B1 | 2,5-diaminopyridine oxidation bases and their use for dyeing of keratin fibres | OREAL (FR) | 2011-09-21 | — | — | EP | disclosed |
| US-7179307-B2 | Use of an extract of myrsine africana in oxidation dyeing for dyeing keratin fibres | L'OREAL, S.A. (FR) | 2007-02-20 | — | — | US | disclosed |
| CN-1250192-C | 2,5-diaminopyridine oxidation color display alkali for dyeing keratin fibre | OREAL (FR) | 2006-04-12 | — | — | CN | disclosed |
| US-20060010618-A1 | Use of an extract of Myrsine africana in oxidation dyeing for dyeing keratin fibres | L'OREAL S.A. | 2006-01-19 | — | — | US | disclosed |
| US-6974485-B2 | Use of an extract of Myrsine africana in oxidation dyeing for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-12-13 | — | — | US | disclosed |
| US-6837908-B2 | 2,5-diaminopyridine oxidation bases for the dyeing of keratin fibres | L'OREAL S.A. (FR) | 2005-01-04 | — | — | US | disclosed |
| US-20030163876-A1 | Novel 2,5-diaminopyridine oxidation bases for the dyeing of keratin fibres | L'OREAL S.A. (FR) | 2003-09-04 | — | — | US | disclosed |
| US-20030115687-A1 | Use of an extract of Myrsine africana in oxidation dyeing for dyeing keratin fibres | L'OREAL S.A. (FR) | 2003-06-26 | — | — | US | disclosed |
| CN-1425365-A | 2,5-diaminopyridine oxidation color display alkali for dyeing keratin fibre | OREAL (FR) | 2003-06-25 | — | — | CN | disclosed |
| EP-1312606-A1 | 2,5-diaminopyridine oxidation bases and their use for dyeing of keratin fibres | L'OREAL (FR) | 2003-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030163876-A1 | Novel 2,5-diaminopyridine oxidation bases for the dyeing of keratin fibres | KRT18, DPYD, DSP | SMPD3 3953/4885PDE10A 3263/4885PRKDC 156/4885 |
| US-20060010618-A1 | Use of an extract of Myrsine africana in oxidation dyeing for dyeing keratin fibres | KRT18, TUBB8, TUBB | SMPD3 3850/4885PDE10A 4604/4885PRKDC 1012/4885 |
| US-20030115687-A1 | Use of an extract of Myrsine africana in oxidation dyeing for dyeing keratin fibres | KRT18, TUBB8, TUBB | SMPD3 3850/4885PDE10A 4604/4885PRKDC 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.