Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419397 | 0.84 | PDE7A (0.42) | MAPTALDH1A1HTTGAALMNA | |
| SCHEMBL21590339 | 0.84 | AKR1C3 (0.47) | MAPTALDH1A1HTTPOLBGAA | |
| SCHEMBL21590352 | 0.84 | MAPT (0.41) | MAPTALDH1A1HTTGAAMEN1 | |
| SCHEMBL26418294 | 0.83 | CARM1 (0.44) | MAPTALDH1A1MCOLN3HTTPOLB | |
| SCHEMBL24123883 | 0.83 | ALDH1A1 (0.41) | MAPTALDH1A1HTTGAAMEN1 | |
| SCHEMBL26417859 | 0.81 | ALDH1A1 (0.41) | MAPTALDH1A1HTTPOLBMEN1 | |
| SCHEMBL21558777 | 0.80 | SOS1 (0.39) | ALDH1A1HTT | |
| SCHEMBL13935733 | 0.77 | MAPT (0.47) | MAPTALDH1A1MCOLN3HTTPOLB | |
| SCHEMBL22839748 | 0.76 | ALDH1A1 (0.60) | MAPTALDH1A1MCOLN3HTTPOLB | |
| SCHEMBL9832991 | 0.76 | ALDH1A1 (0.65) | MAPTALDH1A1MCOLN3HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4169919-A1 | PYRAZOLO[3,4-D]PYRIMIDINE-3-KETONE DERIVATIVE AS WEE-1 INHIBITOR | Wigen Biomedicine Technology (Shanghai) Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| WO-2021254389-A1 | PYRAZOLO[3,4-D]PYRIMIDINE-3-KETONE DERIVATIVE AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2021-12-23 | — | — | WO | disclosed |