Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HPGDS | O60760 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26319518 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL1785557 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL2104811 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL352152 | 0.84 | HPGDS (0.73) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL15754791 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL2554731 | 0.83 | HDAC1 (0.71) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL3412110 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL3098211 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL10037306 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 | |
| SCHEMBL657641 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HPGDSKDM4EHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |