SCHEMBL657641

SCHEMBL657641

O=C(O)c1csc(-c2ccncc2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.70
HPGD P15428 1/20 0.66
KDM4E B2RXH2 2/20 0.60
HPGDS O60760 1/20 0.58
LMNA P02545 2/20 0.57
MAPT P10636 2/20 0.57
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
HDAC1 Q13547 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
MAPK1 P28482 1/20 0.54
AR P10275 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
TLR7 Q9NYK1 1/20 0.51
PTPN1 P18031 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL352152 0.87 HPGDS (0.73) ALDH1A1HPGDKDM4EHPGDSMAPT
SCHEMBL27768683 0.87 HPGD (0.68) ALDH1A1HPGDKDM4ELMNAMAPT
Hydrochloric Acid SCHEMBL6821751 0.85 HPGDS (0.71) ALDH1A1HPGDKDM4EHPGDSMAPT
SCHEMBL8278408 0.84 HPGD (0.69) ALDH1A1HPGDKDM4ELMNAMAPT
SCHEMBL26319518 0.84 ALDH1A1 (0.73) ALDH1A1KDM4EHPGDSMAPTHDAC1
SCHEMBL6202834 0.84 HPGD (0.64) ALDH1A1HPGDLMNAMAPTKMT2A
SCHEMBL1785557 0.84 ALDH1A1 (0.73) ALDH1A1KDM4EHPGDSHDAC1HDAC8
SCHEMBL2104811 0.84 ALDH1A1 (0.73) ALDH1A1KDM4EHPGDSKMT2AMEN1
SCHEMBL4735788 0.84 HPGD (0.64) ALDH1A1HPGDKDM4ELMNAMAPT
SCHEMBL24136179 0.82 ALDH1A1 (0.71) ALDH1A1KDM4EHPGDSHDAC1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102168266-B Circuit board browning liquid suitable for high-temperature halogen-free board DONGGUAN FUMOKE CHEMICAL CO LTD 2013-01-23 CN claimed
CN-101903339-B Substituted N-phenyl-bipyrrolidine carboxamides and their therapeutic use SANOFI AVENTIS 2012-06-27 CN claimed
CN-102168266-A Circuit board browning liquid suitable for high-temperature halogen-free board DONGGUAN FUMOKE CHEMICAL CO LTD 2011-08-31 CN claimed
EP-1727551-B1 PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND A INHIBITOR OF THE RSV FUSION PROTEIN ARROW THERAPEUTICS LTD (GB) 2009-09-09 EP claimed
CN-100496499-C Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the RSV fusion protein ARROW THERAPEUTICS LTD (GB) 2009-06-10 CN claimed
WO-2008073461-A2 ION CHANNEL MODULATORS WYETH (US) 2008-06-19 WO claimed
US-20080139536-A1 Benzodiazepines for Treating or Preventing Rsv Infection NOVARTIS PHARMACEUTICALS CORPORATION (US) 2008-06-12 US claimed
US-20070293482-A1 Process for Preparing Benzodiazepines NOVARTIS PHARMACEUTICALS CORPORATION (US) 2007-12-20 US claimed
US-20070185096-A1 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein NOVARTIS PHARMACEUTICALS CORPORATION (US) 2007-08-09 US claimed
CN-1933841-A Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein ARROW THERAPEUTICS LTD (GB) 2007-03-21 CN claimed
CN-1929848-A Benzodiazepines for treating or preventing or preventing RSV infection ARROW THERAPEUTICS LTD (GB) 2007-03-14 CN claimed
EP-1740185-A1 BENZODIAZEPINES FOR TREATING OR PREVENTING RSV INFECTION Arrow Therapeutics Limited (GB) 2007-01-10 EP claimed
EP-1727551-A1 PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND A INHIBITOR OF THE RSV FUSION PROTEIN Arrow Therapeutics Limited (GB) 2006-12-06 EP claimed
WO-2005089770-A1 BENZODIAZEPINES FOR TREATING OR PREVENTING OR PREVENTING RSV INFECTION ARROW THERAPEUTICS LIMITED (GB) 2005-09-29 WO claimed
WO-2005089771-A1 PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND A INHIBITOR OF THE RSV FUSION PROTEIN ARROW THERAPEUTICS LIMITED (GB) 2005-09-29 WO claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
EP-4743081-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION Pretzel Therapeutics, Inc. (US) 2026-05-20 EP disclosed
WO-2025019407-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION PRETZEL THERAPEUTICS, INC. (US) 2025-01-23 WO disclosed
US-4879295-A ANTIALLERGENS SAWAI PHARMACEUTICAL CO., LTD. (JP) 1989-11-07 US disclosed
EP-0262873-A1 N-tetrazolyl thiazolecarboxamide derivatives and their use SAWAI PHARMACEUTICAL CO., LTD. (JP) 1988-04-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070185096-A1 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein GABRP, TSPO, GABRA1 ALDH1A1 3840/4885HPGD 2885/4885KDM4E 4254/4885
US-20070293482-A1 Process for Preparing Benzodiazepines CNR1, SIGMAR1, GABRA3 ALDH1A1 1301/4885HPGD 1291/4885KDM4E 3243/4885
US-20080139536-A1 Benzodiazepines for Treating or Preventing Rsv Infection CNR1, CBR1, CBR3 ALDH1A1 1328/4885HPGD 1645/4885KDM4E 3844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.