Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PTPRF | P10586 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413970 | 0.84 | KDM4E (0.70) | KDM4EALDH1A1RAB9AHTTPOLB | |
| SCHEMBL167820 | 0.84 | RAB9A (0.58) | KDM4EALDH1A1RAB9AHTTPOLB | |
| SCHEMBL27604873 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1RAB9AHTTPOLB | |
| SCHEMBL9829142 | 0.83 | RAB9A (0.55) | KDM4EALDH1A1RAB9AHTTPOLB | |
| SCHEMBL3934931 | 0.83 | ALDH1A1 (0.56) | KDM4EALDH1A1RAB9AHTTGAA | |
| SCHEMBL31401011 | 0.83 | LMNA (0.55) | KDM4EALDH1A1RAB9AHTTPOLB | |
| SCHEMBL3613493 | 0.83 | RAB9A (0.63) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5734275 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1RAB9AHTTPOLB | |
| Hydrochloric Acid SCHEMBL3613004 | 0.81 | RAB9A (0.61) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5048867 | 0.79 | ECE1 (0.42) | KDM4EALDH1A1RAB9AHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |