Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24136162 | 0.83 | CYP11B1 (0.35) | — | |
| SCHEMBL22434864 | 0.80 | PARP15 (0.33) | HRH4PARP15PARP10TNKS2PARP2 | |
| SCHEMBL24136150 | 0.79 | AR (0.32) | — | |
| SCHEMBL24136189 | 0.79 | MEN1 (0.35) | — | |
| SCHEMBL24136225 | 0.76 | — | — | |
| SCHEMBL24136153 | 0.75 | PDE2A (0.35) | — | |
| SCHEMBL24136224 | 0.74 | — | — | |
| SCHEMBL20505401 | 0.73 | ALDH1A1 (0.35) | — | |
| SCHEMBL24136206 | 0.72 | CYP19A1 (0.35) | CYP1A2 | |
| SCHEMBL24136161 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |