Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434777 | 0.83 | PDE2A (0.35) | PDE2AEPHX2SCN9ARORCKCNH2 | |
| SCHEMBL24136189 | 0.83 | MEN1 (0.35) | — | |
| SCHEMBL20504731 | 0.77 | PDE2A (0.35) | PDE2AEPHX2SCN9AKCNH2TMEM97 | |
| SCHEMBL24136150 | 0.76 | AR (0.32) | — | |
| SCHEMBL24136193 | 0.75 | HRH4 (0.33) | — | |
| SCHEMBL24136162 | 0.74 | CYP11B1 (0.35) | — | |
| SCHEMBL24136206 | 0.73 | CYP19A1 (0.35) | — | |
| SCHEMBL24136225 | 0.68 | — | — | |
| SCHEMBL24136224 | 0.66 | — | — | |
| SCHEMBL24136204 | 0.66 | L3MBTL1 (0.35) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |