Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TTR | P02766 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176786 | 0.83 | PDK1 (0.53) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL1899962 | 0.82 | KMT2A (0.54) | MEN1KMT2ALMNATTRPTGS2 | |
| SCHEMBL26045065 | 0.76 | KMT2A (0.40) | MEN1KMT2ALMNATTRPTGS2 | |
| Hydrochloric Acid SCHEMBL1788307 | 0.75 | TSHR (0.55) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL3529403 | 0.75 | KMT2A (0.55) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL1614730 | 0.74 | TSHR (0.77) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL5546431 | 0.74 | MAPT (0.48) | MEN1KMT2ALMNAPTGS2AKR1C3 | |
| SCHEMBL11653586 | 0.74 | PDK1 (0.44) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL8165575 | 0.74 | NR4A2 (0.47) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL4743711 | 0.74 | TSHR (0.63) | TSHRPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906953-B2 | Pyrrolidine substitute flavones for the treatment of inflammatory disorders | Piramal Enterprises Limited (IN) | 2014-12-09 | — | — | US | disclosed |
| CN-103037860-A | Pyrrolidine Substituted Flavones For The Treatment Of Inflammatory Disorders | PIRAMAL LIFE SCIENCES LTD | 2013-04-10 | — | — | CN | disclosed |
| EP-2538941-A1 | PYRROLIDINE SUBSTITUTED FLAVONES FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Piramal Enterprises Limited (IN) | 2013-01-02 | — | — | EP | disclosed |
| US-20120316216-A1 | PYRROLIDINE SUBSTITUTE FLAVONES FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Piramal Enterprises Limited (IN) | 2012-12-13 | — | — | US | disclosed |
| WO-2011104584-A1 | PYRROLIDINE SUBSTITUTED FLAVONES FOR THE TREATMENT OF INFLAMMATORY DISORDERS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316216-A1 | PYRROLIDINE SUBSTITUTE FLAVONES FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, SYVN1, PAH | TSHR 4713/4885PDK1 342/4885PDK2 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.