Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 11/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143919 | 0.90 | NR1D1 (0.47) | NR1D1LMNAMKNK1MKNK2HTR6 | |
| SCHEMBL24143305 | 0.90 | NR1D1 (0.47) | NR1D1CYP19A1POLBHTR6 | |
| SCHEMBL24144642 | 0.90 | NR1D1 (0.49) | NR1D1CYP19A1KMT2AKDM4ELMNA | |
| SCHEMBL24143255 | 0.90 | NR1D1 (0.47) | NR1D1MKNK1MKNK2ICMTHTR6 | |
| SCHEMBL24143217 | 0.86 | NR1D1 (0.46) | NR1D1KMT2AMEN1LMNA | |
| SCHEMBL24143945 | 0.86 | NR1D1 (0.48) | NR1D1GSK3B | |
| SCHEMBL24144664 | 0.85 | NR1D1 (0.49) | NR1D1CYP19A1KMT2AKDM4EMEN1 | |
| SCHEMBL24143286 | 0.85 | NR1D1 (0.68) | NR1D1 | |
| SCHEMBL24144679 | 0.84 | NR1D1 (0.49) | NR1D1HTR6GSK3B | |
| SCHEMBL24144502 | 0.83 | CYP19A1 (0.47) | NR1D1CYP19A1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |