Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | ICMT | O60725 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NR1D1 | P20393 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143548 | 0.88 | NFATC1 (0.50) | CYP19A1HTR6NR1D1LMNAKDM4E | |
| SCHEMBL24144070 | 0.88 | HTR6 (0.54) | CYP19A1ICMTHTR6NR1D1POLB | |
| SCHEMBL24144386 | 0.87 | LMNA (0.45) | MKNK1MKNK2TAAR1HTR6NR1D1 | |
| SCHEMBL24144383 | 0.87 | CYP19A1 (0.49) | CYP19A1TAAR1HTR6NR1D1POLB | |
| SCHEMBL24144290 | 0.87 | HTR6 (0.41) | CYP19A1HTR6NR1D1ROCK2GSK3B | |
| SCHEMBL24144381 | 0.87 | ICMT (0.50) | ICMTMKNK1MKNK2TAAR1HTR6 | |
| SCHEMBL24143540 | 0.85 | NR1D1 (0.42) | HTR6NR1D1KDM4EMEN1HTT | |
| SCHEMBL24143551 | 0.85 | NR1D1 (0.41) | CYP19A1MKNK1MKNK2HTR6NR1D1 | |
| SCHEMBL24143555 | 0.85 | ROCK2 (0.46) | TAAR1HTR6NR1D1KMT2ACYP3A4 | |
| SCHEMBL24143557 | 0.84 | CYP19A1 (0.45) | CYP19A1MKNK1MKNK2TAAR1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |