Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 12/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 3/20 | 0.37 |
| ▸ | EP300 | Q09472 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143293 | 0.85 | NR1D1 (0.57) | NR1D1 | |
| SCHEMBL24143294 | 0.84 | NR1D1 (0.47) | NR1D1HTR6GSK3B | |
| SCHEMBL24144664 | 0.84 | NR1D1 (0.49) | NR1D1 | |
| SCHEMBL24143302 | 0.84 | NR1D1 (0.48) | NR1D1GSK3B | |
| SCHEMBL24143919 | 0.83 | NR1D1 (0.47) | NR1D1HTR6 | |
| SCHEMBL24143305 | 0.83 | NR1D1 (0.47) | NR1D1HTR6 | |
| SCHEMBL24144682 | 0.83 | NR1D1 (0.72) | NR1D1 | |
| SCHEMBL24144642 | 0.83 | NR1D1 (0.49) | NR1D1HTR6HAT1EP300GSK3B | |
| SCHEMBL24142882 | 0.80 | HTR6 (0.44) | NR1D1HTR6HDAC8 | |
| SCHEMBL24144264 | 0.80 | NR1D1 (0.52) | NR1D1HTR6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |