Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 10/20 | 0.49 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HAT1 | O14929 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143294 | 0.90 | NR1D1 (0.47) | NR1D1GSK3BCYP19A1KDM4ELMNA | |
| SCHEMBL24143945 | 0.89 | NR1D1 (0.48) | NR1D1NFATC1GSK3BDYRK1AHAT1 | |
| SCHEMBL24143919 | 0.87 | NR1D1 (0.47) | NR1D1DYRK1AALDH1A1LMNAHTR6 | |
| SCHEMBL24144664 | 0.86 | NR1D1 (0.49) | NR1D1CYP19A1KDM4EALDH1A1MAPT | |
| SCHEMBL24143305 | 0.85 | NR1D1 (0.47) | NR1D1CYP19A1HTR6 | |
| SCHEMBL24143255 | 0.85 | NR1D1 (0.47) | NR1D1HTR6 | |
| SCHEMBL24144643 | 0.84 | NR1D1 (0.71) | NR1D1 | |
| SCHEMBL24144679 | 0.83 | NR1D1 (0.49) | NR1D1GSK3BHTR6HAT1EP300 | |
| SCHEMBL24143302 | 0.81 | NR1D1 (0.48) | NR1D1NFATC1GSK3BDYRK1A | |
| SCHEMBL24143548 | 0.81 | NFATC1 (0.50) | NR1D1NFATC1GSK3BDYRK1ASERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |