Malonic Acid

Malonic Acid

SCHEMBL2415013

C[Si](C)(C)O[Si](C)(CCCNC(=O)C(C#N)=CC=C(c1ccccc1)c1ccccc1)O[Si](C)(C)C.O=C(O)CC(=O)O

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.39
SMN1; SMN2 Q16637 5/20 0.39
KDM4E B2RXH2 5/20 0.39
ALDH1A1 P00352 7/20 0.38
HPGD P15428 4/20 0.38
APOBEC3A P31941 1/20 0.37
APOBEC3G Q9HC16 1/20 0.37
MAPT P10636 5/20 0.37
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
EGFR P00533 3/20 0.37
MAPK1 P28482 3/20 0.37
POLB P06746 2/20 0.37
CYP1A2 P05177 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37
ALOX15 P16050 2/20 0.37
ALOX12 P18054 2/20 0.37
CYP2C19 P33261 2/20 0.37
RECQL P46063 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2806467 0.97 LMNA (0.40) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL2806471 0.97 LMNA (0.40) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL12496025 0.92 LMNA (0.37) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL1576555 0.92 LMNA (0.37) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL14488715 0.81 CES2 (0.34) LMNAKDM4EALDH1A1HPGDMAPT
SCHEMBL2409914 0.81 PTAFR (0.35) LMNASMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL2409916 0.81 PTAFR (0.35) LMNASMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL4851098 0.80 DNM1 (0.37) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL4851091 0.80 DNM1 (0.37) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL14018852 0.80 DNM1 (0.37) KDM4EALDH1A1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2538914-A1 COMPOSITION COMPRISING A SUPERABSORBENT POLYMER AND A GEMINI SURFACTANT L'Oréal (FR) 2013-01-02 EP disclosed
WO-2011104228-A1 COMPOSITION COMPRISING A SUPERABSORBENT POLYMER AND A GEMINI SURFACTANT L'OREAL (FR) 2011-09-01 WO disclosed