Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL241626 | 1.00 | — | — | |
| Alcohol SCHEMBL8347532 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRPDK1PDK2PDK3 | |
| Tetrahydrofuran SCHEMBL30232 | 0.97 | — | — | |
| Tetrahydrofuran SCHEMBL8412489 | 0.97 | ALDH1A1 (0.57) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Alcohol SCHEMBL3138912 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Tetrahydrofuran SCHEMBL218583 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Tetrahydrofuran SCHEMBL4858668 | 0.93 | — | — | |
| Alcohol SCHEMBL4270003 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Alcohol SCHEMBL15013700 | 0.93 | — | — | |
| Alcohol SCHEMBL7807841 | 0.90 | ALDH1A1 (0.50) | ALDH1A1TSHRPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111036185-B | Amphiphilic cellulose-based adsorbent and preparation method thereof | 福州大学 | 2021-07-13 | — | — | CN | disclosed |
| CN-111036185-A | Amphiphilic cellulose-based adsorbent and preparation method thereof | 福州大学 | 2020-04-21 | — | — | CN | disclosed |