Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419034 | 1.00 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3BACE1KDM4E | |
| SCHEMBL8108438 | 0.83 | HTR6 (0.50) | SLC6A2SLC6A4SLC6A3KMT2AALDH1A1 | |
| SCHEMBL3062717 | 0.82 | SLC6A4 (0.53) | SLC6A2SLC6A4SLC6A3HTR6 | |
| Hydrochloric Acid SCHEMBL6498978 | 0.81 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL1022680 | 0.79 | SLC6A4 (0.56) | SLC6A2SLC6A4SLC6A3KDM4EGLA | |
| SCHEMBL1022681 | 0.79 | SLC6A4 (0.56) | SLC6A2SLC6A4SLC6A3KDM4EGLA | |
| Hydrochloric Acid SCHEMBL1022164 | 0.78 | SLC6A4 (0.55) | SLC6A2SLC6A4SLC6A3KDM4EGLA | |
| SCHEMBL7806038 | 0.74 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KDM4EGLA | |
| SCHEMBL6500944 | 0.74 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3HTR6 | |
| Cadaverine Tartrate SCHEMBL3542909 | 0.74 | SLC6A3 (0.48) | SLC6A2SLC6A4SLC6A3KMT2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367818-B1 | 8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES AND THEIR USE AS MONO-AMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | INITIATOR PHARMA AS (DK) | 2018-07-25 | — | — | EP | disclosed |
| US-8633218-B2 | 8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | ANIONA APS (DK) | 2014-01-21 | — | — | US | disclosed |
| US-20110263640-A1 | 8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-10-27 | — | — | US | disclosed |
| EP-2367818-A1 | 8-AZABICYCLO Ý3.2.1¨OCT-2-ENE DERIVATIVES AND THEIR USE AS MONO-AMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NeuroSearch A/S (DK) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010057848-A1 | 8-AZABICYCLO [3.2.1]OCT-2-ENE DERIVATIVES AND THEIR USE AS MONO-AMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263640-A1 | 8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, SLC18A3 | SLC6A2 2/4885SLC6A4 7/4885SLC6A3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.