Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27371685 | 0.81 | MAPT (0.62) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL24196763 | 0.73 | ALDH1A1 (0.52) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL7510673 | 0.71 | ALDH1A1 (0.47) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL26255153 | 0.70 | ALDH1A1 (0.60) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL26255155 | 0.70 | SMN1; SMN2 (0.56) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL14623890 | 0.70 | CSNK2A2 (0.65) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL8493182 | 0.70 | LDHA (0.44) | ALDH1A1HTTLMNASMN1; SMN2RAB9A | |
| SCHEMBL24197153 | 0.69 | ALDH1A1 (0.59) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL24196742 | 0.69 | SMN1; SMN2 (0.55) | ALDH1A1TP53HTTLMNAL3MBTL1 | |
| SCHEMBL7699390 | 0.69 | ALDH1A1 (0.49) | ALDH1A1TP53HTTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| WO-2022011171-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLKB1, KLK2, KLK1 | ALDH1A1 977/4885TP53 1539/4885HTT 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.