Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26255163 | 0.83 | YTHDC1 (0.53) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL22326727 | 0.76 | ADORA2A (0.69) | ADORA2AADORA1TMIGD3ADORA2BPI4KA | |
| SCHEMBL22326729 | 0.74 | ADORA2A (0.66) | ADORA2AADORA1TMIGD3ADORA2BPI4KA | |
| SCHEMBL21275931 | 0.72 | ADORA2A (0.59) | ADORA2AADORA1TMIGD3ADORA2BPI4KA | |
| SCHEMBL24197146 | 0.71 | YTHDC1 (0.55) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL24197229 | 0.71 | YTHDC1 (0.55) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL24197147 | 0.71 | YTHDC1 (0.55) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL24197039 | 0.70 | ADORA2A (0.60) | ADORA2AADORA1TMIGD3ADORA2BPI4KA | |
| SCHEMBL18548917 | 0.69 | YTHDC1 (0.62) | ADORA2AADORA1TMIGD3ADORA2BPI4KA | |
| SCHEMBL29141662 | 0.68 | ADORA2A (0.63) | ADORA2AADORA1TMIGD3ADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| WO-2022011171-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLKB1, KLK2, KLK1 | ADORA2A 2475/4885ADORA1 3485/4885TMIGD3 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.