Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21455747 | 0.93 | BACE1 (0.38) | BACE1L3MBTL1ALDH1A1LTB4RLTB4R2 | |
| SCHEMBL23617054 | 0.90 | BACE1 (0.38) | BACE1L3MBTL1ALDH1A1LTB4RLTB4R2 | |
| SCHEMBL24199924 | 0.75 | AGBL2 (0.37) | LTB4RLTB4R2KDM4EHSD17B10GAA | |
| SCHEMBL23616975 | 0.67 | ALDH1A1 (0.36) | L3MBTL1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL21455476 | 0.65 | MAPT (0.35) | L3MBTL1ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL6357414 | 0.64 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL5556291 | 0.64 | ALDH1A1 (0.60) | BACE1L3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21456031 | 0.64 | HSD17B10 (0.46) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL16967148 | 0.63 | BACE1 (0.59) | BACE1L3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL16978734 | 0.63 | BACE1 (0.59) | BACE1L3MBTL1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939658-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |