Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24200328 | 0.93 | BACE1 (0.39) | BACE1L3MBTL1ALDH1A1LTB4RLTB4R2 | |
| SCHEMBL23617054 | 0.88 | BACE1 (0.38) | BACE1L3MBTL1ALDH1A1LTB4RLTB4R2 | |
| SCHEMBL24199924 | 0.81 | AGBL2 (0.37) | LTB4RLTB4R2KDM4EHSD17B10GAA | |
| SCHEMBL21455476 | 0.70 | MAPT (0.35) | L3MBTL1ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL23617355 | 0.69 | PDCD1 (0.38) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL21455194 | 0.67 | TBXAS1 (0.45) | L3MBTL1ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL21455523 | 0.66 | ALDH1A1 (0.37) | L3MBTL1ALDH1A1MAPTHTTLMNA | |
| SCHEMBL6357414 | 0.66 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL5556291 | 0.65 | ALDH1A1 (0.60) | BACE1L3MBTL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21456031 | 0.65 | HSD17B10 (0.46) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |