Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26494859 | 0.89 | NAAA (0.58) | NAAADNM1CASP2 | |
| SCHEMBL20158796 | 0.88 | DNM1 (0.42) | NAAADNM1KDM4EALOX15HSD17B10 | |
| SCHEMBL5146559 | 0.86 | ALDH1A1 (0.54) | NAAADNM1KDM4EALOX15MEN1 | |
| SCHEMBL116852 | 0.80 | DNM1 (0.73) | NAAADNM1DRD2CASP2ALDH1A1 | |
| SCHEMBL115307 | 0.80 | DNM1 (0.73) | NAAADNM1DRD2CASP2ALDH1A1 | |
| SCHEMBL115857 | 0.80 | DNM1 (0.73) | NAAADNM1DRD2CASP2ALDH1A1 | |
| SCHEMBL115785 | 0.80 | DNM1 (0.73) | NAAADNM1DRD2CASP2ALDH1A1 | |
| SCHEMBL11146017 | 0.80 | DRD2 (0.49) | DNM1KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL29286424 | 0.80 | DNM1 (0.67) | NAAADNM1MEN1KMT2ADRD2 | |
| SCHEMBL29286446 | 0.80 | DNM1 (0.67) | NAAADNM1MEN1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538529-B1 | SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-KB PATHWAYS | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT (DE) | 2022-01-19 | — | — | EP | disclosed |