Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24619670 | 0.77 | APP (0.34) | APPPTPN1BACE1FNTAFNTB | |
| SCHEMBL2624847 | 0.76 | APP (0.38) | APPPTPN1BACE1ABCG2 | |
| SCHEMBL2624846 | 0.76 | APP (0.38) | APPPTPN1BACE1ABCG2 | |
| SCHEMBL2624862 | 0.76 | APP (0.38) | APPPTPN1BACE1ABCG2 | |
| SCHEMBL30678564 | 0.76 | APP (0.38) | APPPTPN1BACE1ABCG2 | |
| SCHEMBL21538203 | 0.73 | ALOX5 (0.52) | — | |
| SCHEMBL2624816 | 0.69 | ALOX5 (0.33) | APPFNTAFNTB | |
| SCHEMBL31540354 | 0.69 | ALOX15 (0.43) | APPALDH1A1CYP3A4CYP2C9ALOX15 | |
| SCHEMBL31540353 | 0.69 | ALOX15 (0.43) | APPALDH1A1CYP3A4CYP2C9ALOX15 | |
| SCHEMBL22863219 | 0.65 | PTPN2 (0.42) | APPCYP3A4SMN1; SMN2PTPN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939659-A1 | DRUG AND METHOD FOR TREATING OR PREVENTING COMPLICATIONS FROM DIABETES, USING SAID DRUG | Showa University (JP) | 2022-01-19 | — | — | EP | disclosed |