Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761495 | 0.82 | MKNK1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2EGFR | |
| SCHEMBL9115905 | 0.77 | EGFR (0.66) | EGFRCSF1R | |
| SCHEMBL23761308 | 0.76 | MKNK1 (0.48) | SRD5A1SRD5A2MKNK1MKNK2EIF4E | |
| SCHEMBL24202017 | 0.75 | NOTUM (0.41) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL24202076 | 0.73 | MKNK1 (0.34) | NPC1RAB9AMAPTSMN1; SMN2EGFR | |
| SCHEMBL23761492 | 0.73 | MKNK1 (0.45) | SRD5A1SRD5A2MKNK1MKNK2EIF4E | |
| SCHEMBL23761530 | 0.73 | NOTUM (0.40) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24201824 | 0.73 | MKNK1 (0.45) | EGFRSRD5A1SRD5A2MKNK1MKNK2 | |
| SCHEMBL23761642 | 0.73 | EIF4E (0.35) | NPC1RAB9AMAPTSMN1; SMN2EGFR | |
| SCHEMBL24201711 | 0.72 | MKNK1 (0.44) | SMN1; SMN2ALDH1A1SRD5A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |