Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.37 |
| ▸ | EIF4E | P06730 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761515 | 0.93 | MKNK1 (0.45) | MKNK1MKNK2EIF4EKDM4EALDH1A1 | |
| SCHEMBL23761640 | 0.91 | MKNK1 (0.34) | MKNK1MKNK2EIF4EKDM4ESRD5A1 | |
| SCHEMBL24201720 | 0.83 | KMT2A (0.40) | MKNK1MKNK2EIF4EALDH1A1SRD5A1 | |
| SCHEMBL24201711 | 0.83 | MKNK1 (0.44) | MKNK1MKNK2EIF4EKDM4EALDH1A1 | |
| SCHEMBL24202016 | 0.81 | MKNK1 (0.36) | MKNK1MKNK2EIF4EKDM4EALDH1A1 | |
| SCHEMBL24201665 | 0.80 | MKNK1 (0.47) | MKNK1MKNK2EIF4EALDH1A1LMNA | |
| SCHEMBL23761540 | 0.78 | MKNK1 (0.36) | MKNK1MKNK2EIF4EKDM4EALDH1A1 | |
| SCHEMBL23761323 | 0.78 | MKNK1 (0.48) | MKNK1MKNK2EIF4ELMNANOTUM | |
| SCHEMBL23761494 | 0.77 | MKNK1 (0.44) | MKNK1MKNK2EIF4EMEN1KMT2A | |
| SCHEMBL24201824 | 0.76 | MKNK1 (0.45) | MKNK1MKNK2EIF4ELMNASRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |