Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | PDE9A | O76083 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22274905 | 0.86 | PDE9A (0.38) | ALDH1A1PDE9AL3MBTL1S1PR1KDM4E | |
| SCHEMBL29901275 | 0.86 | PDE9A (0.38) | ALDH1A1PDE9AL3MBTL1S1PR1KDM4E | |
| SCHEMBL20870098 | 0.77 | ALDH1A1 (0.41) | ALDH1A1PDE9AL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL22298196 | 0.76 | RECQL (0.40) | ALDH1A1PDE9AL3MBTL1S1PR1KDM4E | |
| SCHEMBL24063619 | 0.76 | ALDH1A1 (0.40) | ALDH1A1PDE9AL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL29901239 | 0.74 | PDE9A (0.50) | PDE9A | |
| SCHEMBL8137384 | 0.72 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1KDM4EHPGDHSD17B10 | |
| SCHEMBL28798602 | 0.69 | L3MBTL1 (0.41) | L3MBTL1KDM4EMAPTPDE10A | |
| SCHEMBL8142980 | 0.67 | KMT2A (0.51) | ALDH1A1L3MBTL1KDM4EHPGDMAPT | |
| SCHEMBL13329219 | 0.67 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939588-A1 | USES OF PHOSPHODIESTERASE INHIBITORS | Transthera Sciences (Nanjing), Inc. (CN) | 2022-01-19 | — | — | EP | disclosed |