Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980285 | 0.78 | MEN1 (0.40) | VCPPKMALDH1A1POLBRECQL | |
| SCHEMBL6013549 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL4651637 | 0.77 | MEN1 (0.39) | VCPPKMALDH1A1POLBRECQL | |
| SCHEMBL24171724 | 0.77 | VCP (0.38) | VCPPKMALDH1A1POLBRECQL | |
| SCHEMBL24204805 | 0.75 | CASP2 (0.48) | CYP2C9CYP2C19TDP1PKMALDH1A1 | |
| Hydrochloric Acid SCHEMBL31097152 | 0.75 | ALDH1A1 (0.43) | CYP2C9CYP2C19VCPPKMALDH1A1 | |
| SCHEMBL24204325 | 0.75 | TDP1 (0.43) | CYP2C9CYP2C19VCPTDP1ALDH1A1 | |
| SCHEMBL26005369 | 0.75 | MEN1 (0.36) | POLB | |
| SCHEMBL16219402 | 0.74 | VCP (0.39) | VCPPKMALDH1A1POLBRECQL | |
| SCHEMBL20466373 | 0.74 | WHR1 (0.42) | VCPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022012623-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |