Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425563 | 0.90 | RAB9A (0.55) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL10247006 | 0.86 | HSD17B10 (0.66) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL2419464 | 0.82 | HSD17B10 (0.73) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL2427334 | 0.79 | RAB9A (0.60) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL255110 | 0.78 | HSD17B10 (0.43) | RAB9ANPC1HSD17B10KDM4EMAPK1 | |
| SCHEMBL2179717 | 0.74 | TRPM8 (0.58) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL25523259 | 0.74 | ALDH1A1 (0.54) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL10247004 | 0.73 | HSD17B10 (0.61) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL255583 | 0.73 | HSD17B10 (0.61) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL255810 | 0.73 | HSD17B10 (0.64) | RAB9ANPC1L3MBTL1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |