Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2420643 | 0.90 | RAB9A (0.57) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL2419464 | 0.80 | HSD17B10 (0.73) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL10247006 | 0.77 | HSD17B10 (0.66) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL2427334 | 0.76 | RAB9A (0.60) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL10247004 | 0.76 | HSD17B10 (0.61) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL2423902 | 0.76 | LMNA (0.51) | L3MBTL1ALDH1A1TP53TSHRCSNK2A2 | |
| SCHEMBL173331 | 0.75 | HSD17B10 (0.59) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL10246874 | 0.74 | HSD17B10 (0.58) | RAB9ANPC1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL255850 | 0.73 | HSD17B10 (0.57) | L3MBTL1HSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL27766401 | 0.73 | CHRNB2 (0.65) | RAB9ANPC1L3MBTL1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |