Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.63 |
| ▸ | FADS1 | O60427 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690577 | 0.83 | KEAP1 (0.61) | KEAP1FADS1HDAC1CES2CES1 | |
| SCHEMBL246382 | 0.82 | CES2 (0.61) | KEAP1FADS1HDAC1CES2CES1 | |
| SCHEMBL29520286 | 0.82 | KEAP1 (0.56) | KEAP1FADS1HDAC1CES2CES1 | |
| SCHEMBL13753884 | 0.82 | KEAP1 (0.56) | KEAP1FADS1HDAC1CES2CES1 | |
| SCHEMBL7698671 | 0.81 | KEAP1 (0.54) | KEAP1FADS1HDAC1CES2CES1 | |
| SCHEMBL15630978 | 0.81 | KEAP1 (0.59) | KEAP1FADS1HDAC1MAPTKDM4E | |
| SCHEMBL1639721 | 0.81 | P2RX1 (0.54) | KEAP1CES2CES1ALDH1A1GFER | |
| SCHEMBL1559256 | 0.80 | KEAP1 (0.58) | KEAP1FADS1HDAC1CES2CES1 | |
| SCHEMBL2700198 | 0.80 | MAPT (0.59) | FADS1ALDH1A1GFERMAPTKDM4E | |
| SCHEMBL22466424 | 0.79 | F2R (0.51) | KEAP1CES2CES1ALDH1A1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017524-A1 | ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS | THE BROAD INSTITUTE, INC. (US) | 2022-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220017524-A1 | ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS | AHR, ESRRA, AR | KEAP1 868/4885FADS1 278/4885HDAC1 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.