Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | FADS1 | O60427 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13753884 | 1.00 | KEAP1 (0.56) | KEAP1FADS1NOS2HDAC1BRAF | |
| SCHEMBL13181106 | 0.87 | HDAC1 (0.45) | KEAP1HDAC1L3MBTL1CA2CA4 | |
| SCHEMBL6366517 | 0.84 | HTT (0.55) | KEAP1FADS1HDAC1CA2CA4 | |
| SCHEMBL13753059 | 0.83 | CES2 (0.55) | L3MBTL1CA2CA4LMNACES2 | |
| SCHEMBL24210299 | 0.82 | KEAP1 (0.63) | KEAP1FADS1HDAC1BRAFKDM4E | |
| SCHEMBL15630978 | 0.82 | KEAP1 (0.59) | KEAP1FADS1HDAC1CA2KDM4E | |
| SCHEMBL15402062 | 0.81 | CFTR (0.51) | KEAP1FADS1HDAC1BRAFJAK2 | |
| SCHEMBL6887760 | 0.81 | NAAA (0.48) | NOS2HDAC1BRAFCA2LMNA | |
| SCHEMBL13753816 | 0.81 | HPGD (0.49) | NOS2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL1911846 | 0.81 | P2RX7 (0.44) | L3MBTL1CA2CA4LMNACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479830-B2 | Homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2025-11-25 | — | — | US | disclosed |
| CN-114502549-B | Homopiperazinyl and homopiperidinyl quinazolin-4 (3H) -one derivatives having multimodal activity against pain | 埃斯特韦制药股份公司 | 2024-10-25 | — | — | CN | disclosed |
| US-20220380345-A1 | HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2022-12-01 | — | — | US | disclosed |
| EP-4041391-A1 | HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502549-A | Homopiperazinyl and homopiperidinyl quinazolin-4 (3H) -one derivatives having multimodal activity against pain | 埃斯特韦制药股份公司 | 2022-05-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12479830-B2 | Homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having multimodal activity against pain | OPRD1, SIGMAR1, OPRK1 | KEAP1 3384/4885FADS1 4642/4885NOS2 2193/4885 |
| US-20220380345-A1 | HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRD1, SIGMAR1, OPRK1 | KEAP1 3384/4885FADS1 4642/4885NOS2 2193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.