Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | CD40 | P25942 | 3/20 | 0.43 |
| ▸ | CD40LG | P29965 | 3/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHAT | P28329 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434635 | 0.80 | GRIN2D (0.31) | MAPTMEN1KMT2A | |
| SCHEMBL27401064 | 0.74 | KMT2A (0.47) | KDM4EALDH1A1MAPTHPGDCYP1A2 | |
| SCHEMBL11759224 | 0.74 | TTR (0.59) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL25957148 | 0.72 | MMP1 (0.33) | — | |
| SCHEMBL23178061 | 0.72 | TTR (0.64) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL26885009 | 0.72 | TTR (0.56) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL18769044 | 0.69 | TTR (0.60) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL22268029 | 0.69 | GAA (0.42) | TSHRKDM4EMAPTHPGDMEN1 | |
| SCHEMBL6242038 | 0.69 | CD40 (0.61) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL6911279 | 0.69 | TTR (0.64) | TTRFABP4CCNA2CDK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247558-B2 | NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | LILLY CO ELI (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-2247558-B1 | NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | LILLY CO ELI (US) | 2022-02-02 | — | — | EP | disclosed |