Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.36 |
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424070 | 1.00 | HCAR3 (0.42) | HCAR3HSP90AA1HSP90AB1NNMTGABRP | |
| SCHEMBL2424707 | 0.91 | HSP90AA1 (0.41) | HCAR3HSP90AA1HSP90AB1NNMTGABRP | |
| SCHEMBL2430012 | 0.88 | HSP90AA1 (0.35) | HCAR3HSP90AA1HSP90AB1NNMTGABRP | |
| SCHEMBL2423473 | 0.88 | GRM1 (0.38) | HSP90AA1HSP90AB1NNMTGABRPGABRD | |
| SCHEMBL2425814 | 0.85 | JAK2 (0.38) | HSP90AA1HSP90AB1NNMTGABRPGABRD | |
| SCHEMBL2425812 | 0.85 | JAK2 (0.38) | HSP90AA1HSP90AB1NNMTGABRPGABRD | |
| SCHEMBL2425735 | 0.84 | CA1 (0.41) | HCAR3KDM4EGAAALDH1A1GLA | |
| SCHEMBL2423486 | 0.84 | CA1 (0.41) | HCAR3KDM4EGAAALDH1A1GLA | |
| SCHEMBL13450924 | 0.84 | CA1 (0.41) | HCAR3KDM4EGAAALDH1A1GLA | |
| SCHEMBL2424142 | 0.84 | HSP90AA1 (0.46) | HCAR3HSP90AA1HSP90AB1NNMTGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | disclosed |
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | HCAR3 1036/4885HSP90AA1 1888/4885HSP90AB1 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.