Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253912 | 0.89 | BPTF (0.37) | CYP11B2ADAMTS5 | |
| SCHEMBL24253590 | 0.87 | MMP2 (0.33) | CYP11B2RAD51SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL26307735 | 0.86 | MAPT (0.33) | ADAMTS5PDE4BPDE4DADRB1 | |
| SCHEMBL24253513 | 0.80 | SLC6A3 (0.36) | CYP11B2RAD51SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30423624 | 0.80 | SLC6A3 (0.36) | CYP11B2RAD51SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30423977 | 0.76 | TSHR (0.39) | CYP11B2ADAMTS5 | |
| SCHEMBL24253711 | 0.76 | TSHR (0.39) | CYP11B2ADAMTS5 | |
| Hydrochloric Acid SCHEMBL30494641 | 0.75 | TSHR (0.38) | ADAMTS5 | |
| SCHEMBL26307724 | 0.74 | RAD51 (0.39) | CYP11B2RAD51SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL26307736 | 0.74 | CCR1 (0.33) | ADAMTS5ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708366-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2023-07-25 | — | — | US | disclosed |
| US-20220048909-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708366-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | REN, NR3C2, PKD1 | CYP11B2 22/4885RAD51 3303/4885SLC6A2 851/4885 |
| US-20220048909-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | REN, NR3C2, PKD1 | CYP11B2 22/4885RAD51 3303/4885SLC6A2 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.