Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.35 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253982 | 0.83 | TNIK (0.39) | GPR119TNIKPIK3CD | |
| SCHEMBL24253785 | 0.83 | TNIK (0.60) | TNIK | |
| SCHEMBL24254069 | 0.77 | TNIK (0.37) | GPR119TNIKCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL24253780 | 0.73 | CYP2D6 (0.48) | CYP2D6CYP1A2MAPTCYP3A4ALDH1A1 | |
| SCHEMBL24253879 | 0.70 | TNIK (0.60) | TNIK | |
| SCHEMBL24254072 | 0.68 | TNIK (0.56) | TNIK | |
| SCHEMBL24253816 | 0.67 | GPR119 (0.46) | GPR119PIK3CDMAPTJAK2JAK3 | |
| SCHEMBL24253971 | 0.65 | CYP2D6 (0.48) | CYP2D6CYP1A2MAPTCYP3A4ALDH1A1 | |
| SCHEMBL24253970 | 0.65 | CYP2D6 (0.58) | CYP2D6CYP1A2MAPTALDH1A1LMNA | |
| SCHEMBL24253870 | 0.65 | CYP2D6 (0.56) | CYP2D6CYP1A2MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |