Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20646989 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL24254064 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| Bromide SCHEMBL8310882 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL7412453 | 0.78 | NR4A2 (0.51) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL17303476 | 0.77 | NOTUM (0.58) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL16563643 | 0.77 | MAPT (0.51) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL11501154 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL321724 | 0.76 | LMNA (0.61) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL23631819 | 0.76 | PTPN1 (0.41) | MAPTRXFP1LMNAKMT2A | |
| SCHEMBL3407808 | 0.75 | PLOD2 (0.58) | KDM4EALDH1A1MAPK1NOTUMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |