Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8310882 | 0.98 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NOTUMPTPN1 | |
| SCHEMBL20646989 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL7412453 | 0.81 | NR4A2 (0.51) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL17303476 | 0.81 | NOTUM (0.58) | KDM4EALDH1A1MAPK1NOTUMPTPN1 | |
| SCHEMBL16563643 | 0.80 | MAPT (0.51) | KDM4EALDH1A1MAPK1NOTUMPTPN1 | |
| SCHEMBL24253972 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL11501154 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMPTPN1 | |
| SCHEMBL321724 | 0.80 | LMNA (0.61) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL3407808 | 0.79 | PLOD2 (0.58) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL14376685 | 0.79 | LMNA (0.69) | KDM4EALDH1A1LMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |