Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.58 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.56 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500932 | 0.82 | KDM4E (0.50) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL24254064 | 0.79 | KDM4E (0.50) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL20646989 | 0.79 | KDM4E (0.50) | TP53KDM4EALDH1A1MAPK1NOTUM | |
| Bromide SCHEMBL8310882 | 0.78 | KDM4E (0.49) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL29356405 | 0.77 | DGAT1 (0.47) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL7412453 | 0.77 | NR4A2 (0.51) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL17303476 | 0.76 | NOTUM (0.58) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL3431061 | 0.76 | PLOD2 (0.59) | PLOD2PLOD3PLOD1MAPTLMNA | |
| SCHEMBL1364657 | 0.76 | AOC2 (0.58) | DGAT1TP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL24253972 | 0.75 | KDM4E (0.46) | DGAT1TP53KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962834-B2 | Modulators of amyloid beta | HOFFMANN-LA ROCHE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2257541-B1 | MODULATORS FOR AMYLOID BETA | HOFFMANN LA ROCHE (CH) | 2013-08-14 | — | — | EP | disclosed |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | HOFFMANN-LA ROCHE INC. (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE, INC. | 2009-08-27 | — | — | US | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | APP, PSEN1, APOB | PLOD2 912/4885PLOD3 527/4885PLOD1 1173/4885 |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | APP, PSEN1, APOB | PLOD2 873/4885PLOD3 514/4885PLOD1 1104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.