Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254623 | 0.82 | KCNQ2 (0.53) | KCNQ2MEN1KMT2ANPC1HTT | |
| SCHEMBL24254530 | 0.79 | NPC1 (0.68) | KMT2ANPC1HTTGAAMAPT | |
| SCHEMBL20195371 | 0.67 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1 | |
| SCHEMBL24254539 | 0.67 | MAPT (0.53) | KCNQ2MEN1KMT2AHTTTP53 | |
| SCHEMBL24254523 | 0.66 | HPGD (0.59) | MEN1KMT2ARAB9AHTTTP53 | |
| SCHEMBL30795476 | 0.65 | KCNQ2 (0.52) | KCNQ2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2434675 | 0.65 | KCNQ2 (0.52) | KCNQ2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5107741 | 0.65 | ALDH1A1 (0.50) | KCNQ2KMT2ARAB9AHTTTP53 | |
| SCHEMBL13329762 | 0.65 | SRC (0.52) | KCNQ2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL22897441 | 0.64 | SMN1; SMN2 (0.60) | MEN1KMT2ANPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |