Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SELL | P14151 | 1/20 | 0.46 |
| ▸ | SELP | P16109 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254545 | 0.89 | SELL (0.45) | HPGDPOLBLMNAL3MBTL1KMT2A | |
| SCHEMBL24254498 | 0.88 | ALDH1A1 (0.63) | POLBLMNAALDH1A1KMT2AHTT | |
| SCHEMBL24254539 | 0.84 | MAPT (0.53) | LMNAALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL24254578 | 0.83 | L3MBTL1 (0.57) | POLBLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL24254575 | 0.83 | MAPT (0.53) | POLBLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL24254500 | 0.76 | ALDH1A1 (0.78) | HPGDLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7516248 | 0.76 | HPGD (1.00) | HPGDPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL25964181 | 0.74 | HPGD (0.62) | HPGDPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL24254579 | 0.73 | MEN1 (0.57) | POLBALDH1A1L3MBTL1KMT2AHTT | |
| SCHEMBL24254486 | 0.72 | KMT2A (0.62) | LMNAALDH1A1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |