Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29353516 | 0.76 | HDAC6 (0.68) | HDAC6BACE1MEN1KMT2ACYP1A2 | |
| SCHEMBL1040774 | 0.76 | HDAC6 (0.68) | HDAC6BACE1MEN1KMT2ACYP1A2 | |
| SCHEMBL24254528 | 0.73 | ALDH1A1 (0.50) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3235742 | 0.73 | SMN1; SMN2 (0.47) | HDAC6BACE1MEN1KMT2ACYP1A2 | |
| SCHEMBL11274390 | 0.73 | PKM (0.52) | HDAC6BACE1HSD17B10KDM4EMAPT | |
| SCHEMBL15311091 | 0.73 | MAPT (0.44) | HDAC6BACE1MEN1KMT2ACYP1A2 | |
| SCHEMBL29922357 | 0.71 | BACE1 (0.65) | HDAC6BACE1MEN1KMT2ACYP1A2 | |
| SCHEMBL396451 | 0.71 | BACE1 (0.65) | HDAC6BACE1MEN1KMT2ACYP1A2 | |
| SCHEMBL13374030 | 0.71 | GLA (0.49) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14074467 | 0.70 | NAMPT (0.44) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |