Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TREH | O43280 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.36 |
| ▸ | CDA | P32320 | 7/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23705442 | 1.00 | TREH (0.36) | TREHLMNAGBA1LGALS3CDA | |
| SCHEMBL23705299 | 0.82 | LMNA (0.37) | TREHLMNAGBA1LGALS3CDA | |
| SCHEMBL24256353 | 0.82 | LMNA (0.37) | TREHLMNAGBA1LGALS3CDA | |
| SCHEMBL30180597 | 0.79 | ALDH1A1 (0.36) | TREHLMNACDAMAPTPTPN1 | |
| SCHEMBL26879311 | 0.79 | ALDH1A1 (0.36) | TREHLMNACDAMAPTPTPN1 | |
| SCHEMBL24256710 | 0.79 | ALDH1A1 (0.36) | TREHLMNACDAMAPTPTPN1 | |
| SCHEMBL25346410 | 0.79 | ALDH1A1 (0.36) | TREHLMNACDAMAPTPTPN1 | |
| SCHEMBL24256834 | 0.77 | LMNA (0.33) | TREHLMNAGBA1LGALS3CDA | |
| SCHEMBL26879310 | 0.77 | LMNA (0.33) | TREHLMNAGBA1LGALS3CDA | |
| SCHEMBL23705298 | 0.76 | LGALS3 (0.33) | TREHLMNAGBA1LGALS3CDA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240072809-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | US | disclosed |
| US-11819551-B2 | ASGPR-binding compounds for the degradation of extracellular proteins | AVILAR THERAPEUTICS, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| WO-2022035997-A1 | IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS | AVILAR THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11819551-B2 | ASGPR-binding compounds for the degradation of extracellular proteins | ASGR1, ENGASE, FCGR2A | TREH 2371/4885LMNA 2955/4885GBA1 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.