Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257490 | 0.89 | EGLN1 (0.63) | EGLN1EGLN3 | |
| SCHEMBL24257632 | 0.87 | EGLN1 (0.56) | EGLN1EGLN3 | |
| SCHEMBL24257805 | 0.76 | EGLN1 (0.47) | EGLN1 | |
| SCHEMBL24257465 | 0.75 | EGLN1 (0.66) | EGLN1EGLN3 | |
| SCHEMBL24257816 | 0.75 | EGLN1 (0.47) | EGLN1PIN1 | |
| SCHEMBL18736097 | 0.73 | EGLN1 (0.78) | EGLN1EGLN3 | |
| SCHEMBL1658418 | 0.69 | GRM5 (0.55) | EGLN1HSP90AA1HSP90AB1PIN1GRM5 | |
| SCHEMBL24257742 | 0.68 | GABRA1 (0.41) | EGLN1EGLN3 | |
| SCHEMBL13310735 | 0.67 | PIN1 (0.43) | PIN1 | |
| SCHEMBL18736103 | 0.67 | EGLN1 (0.61) | EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |