Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA4 | P22748 | 4/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257488 | 0.89 | EGLN1 (0.50) | EGLN1EGLN2 | |
| SCHEMBL24257710 | 0.85 | EGLN1 (0.52) | EGLN1EGLN2 | |
| SCHEMBL24257805 | 0.78 | EGLN1 (0.47) | EGLN1EGLN2NPC1HPGD | |
| SCHEMBL24257851 | 0.75 | EGLN1 (0.49) | EGLN1PIN1 | |
| SCHEMBL30453191 | 0.72 | EGLN1 (0.48) | EGLN1EGLN2KMT2A | |
| SCHEMBL24257709 | 0.72 | EGLN1 (0.48) | EGLN1EGLN2KMT2A | |
| SCHEMBL11762489 | 0.72 | L3MBTL1 (0.64) | CA2CA4L3MBTL1KMT2ATDP1 | |
| SCHEMBL24257742 | 0.70 | GABRA1 (0.41) | EGLN1 | |
| SCHEMBL24257711 | 0.70 | GRM4 (0.48) | EGLN1KMT2ATDP1NPC1HPGD | |
| SCHEMBL13310735 | 0.69 | PIN1 (0.43) | PIN1L3MBTL1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |