Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | NPY1R | P25929 | 4/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12422869 | 0.89 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BNPY1RNPY5R | |
| SCHEMBL9567984 | 0.82 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BNPY1RNPY5R | |
| SCHEMBL599314 | 0.80 | CYP19A1 (0.54) | ADRA1DADRA1AADRA1BMTNR1AMTNR1B | |
| SCHEMBL9082016 | 0.78 | ADRA1D (0.74) | ADRA1DADRA1AADRA1BHTR1AHTR1D | |
| SCHEMBL9139949 | 0.77 | HTR1A (0.53) | ADRA1DADRA1AADRA1BMTNR1AMTNR1B | |
| SCHEMBL15701675 | 0.76 | CYP19A1 (0.54) | ADRA1DADRA1AADRA1BMTNR1AMTNR1B | |
| SCHEMBL1689627 | 0.76 | CYP19A1 (0.54) | ADRA1DADRA1AADRA1BMTNR1AMTNR1B | |
| SCHEMBL6570371 | 0.76 | CYP19A1 (0.54) | ADRA1DADRA1AADRA1BMTNR1AMTNR1B | |
| SCHEMBL8713442 | 0.76 | MTNR1A (0.52) | ADRA1DADRA1AADRA1BNPY1RNPY5R | |
| SCHEMBL9629132 | 0.76 | NPY5R (0.60) | ADRA1DADRA1AADRA1BNPY1RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |