Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657912 | 0.87 | CREBBP (0.41) | RIPK1CREBBPABCB1HDAC6KCNQ2 | |
| SCHEMBL8485212 | 0.76 | NR1H2 (0.62) | CREBBPABCB1MEN1KMT2ANOTUM | |
| SCHEMBL31070562 | 0.75 | CREBBP (0.52) | CREBBPABCB1NOTUMPLA2G7ALDH1A1 | |
| SCHEMBL13002326 | 0.73 | NOTUM (0.61) | RIPK1MEN1KMT2ANOTUMALDH1A1 | |
| SCHEMBL24258489 | 0.72 | CREBBP (0.56) | CREBBP | |
| SCHEMBL19657828 | 0.72 | CREBBP (0.36) | RIPK1CREBBPABCB1GRIN2BKCNQ2 | |
| SCHEMBL19657386 | 0.72 | CREBBP (0.36) | RIPK1CREBBPABCB1HDAC6GRIN2B | |
| SCHEMBL27306474 | 0.69 | CYP1A2 (0.47) | RIPK1ABCB1MEN1KMT2AHDAC6 | |
| SCHEMBL19657619 | 0.69 | RIPK1 (0.37) | RIPK1HDAC6TMEM97SIGMAR1 | |
| SCHEMBL13127512 | 0.68 | NOTUM (0.55) | RIPK1MEN1KMT2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |