Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 17/20 | 0.56 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258486 | 0.84 | CREBBP (0.61) | CREBBPBRD4AXLTYRO3MERTK | |
| SCHEMBL19657733 | 0.75 | CREBBP (0.50) | CREBBPAXLTYRO3MERTK | |
| SCHEMBL19644201 | 0.73 | CREBBP (0.76) | CREBBPBRD4RET | |
| SCHEMBL19657724 | 0.73 | CREBBP (0.50) | CREBBPBRD4EP300 | |
| SCHEMBL24258523 | 0.73 | GPR142 (0.35) | CREBBP | |
| SCHEMBL24258482 | 0.72 | RIPK1 (0.45) | CREBBP | |
| SCHEMBL19643782 | 0.72 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL30117226 | 0.72 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL19657619 | 0.68 | RIPK1 (0.37) | — | |
| SCHEMBL21024011 | 0.66 | CREBBP (0.41) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |