Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258523 | 0.83 | GPR142 (0.35) | RIPK1HDAC6 | |
| SCHEMBL19657912 | 0.81 | CREBBP (0.41) | RIPK1HDAC6TMEM97SIGMAR1 | |
| SCHEMBL24258482 | 0.69 | RIPK1 (0.45) | RIPK1HDAC6TMEM97SIGMAR1 | |
| SCHEMBL19657828 | 0.69 | CREBBP (0.36) | RIPK1 | |
| SCHEMBL19657386 | 0.69 | CREBBP (0.36) | RIPK1HDAC6 | |
| SCHEMBL24258489 | 0.68 | CREBBP (0.56) | — | |
| SCHEMBL27347680 | 0.66 | MAPT (0.41) | HDAC6 | |
| SCHEMBL19657616 | 0.64 | HDAC6 (0.32) | RIPK1HDAC6TMEM97SIGMAR1 | |
| SCHEMBL24258486 | 0.63 | CREBBP (0.61) | — | |
| SCHEMBL19657581 | 0.60 | CREBBP (0.58) | HDAC6TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |