Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258686 | 0.85 | MIF (0.42) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL24602576 | 0.78 | CNR2 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL24259025 | 0.78 | POLB (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL24451759 | 0.76 | HDAC2 (0.43) | HDAC2HDAC1HDAC8ALDH1A1 | |
| SCHEMBL24258740 | 0.76 | L3MBTL1 (0.39) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL24259698 | 0.75 | L3MBTL1 (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL24092039 | 0.72 | POLB (0.40) | AKR1C4AKR1C3AKR1C2AKR1C1L3MBTL1 | |
| SCHEMBL4228952 | 0.72 | AKR1C4 (0.45) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL1786515 | 0.71 | L3MBTL1 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1HSD11B1 | |
| SCHEMBL6332424 | 0.70 | USP7 (0.46) | AKR1C4AKR1C3AKR1C2AKR1C1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713312-B2 | Substituted bicyclic compounds as farnesoid X receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-01 | — | — | US | disclosed |
| US-20220135550-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-05 | — | — | US | disclosed |
| US-11254663-B2 | Substituted bicyclic compounds as farnesoid X receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135550-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | FXR1, NR1H4, FXR2 | AKR1C4 502/4885AKR1C3 344/4885AKR1C2 553/4885 |
| US-11254663-B2 | Substituted bicyclic compounds as farnesoid X receptor modulators | FXR1, NR1H4, FXR2 | AKR1C4 502/4885AKR1C3 344/4885AKR1C2 553/4885 |
| US-11713312-B2 | Substituted bicyclic compounds as farnesoid X receptor modulators | FXR1, NR1H4, FXR2 | AKR1C4 502/4885AKR1C3 344/4885AKR1C2 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.